BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.babraham.ac.uk
X-WR-TIMEZONE:UTC
X-PUBLISHED-TTL:P1W
BEGIN:VTIMEZONE
TZID:UTC
X-LIC-LOCATION:UTC
END:VTIMEZONE
BEGIN:VEVENT
UID:8366804473eeec30b90616c852b94f39
DTSTART;TZID=UTC:20210922T150000
SEQUENCE:0
TRANSP:OPAQUE
DTEND;TZID=UTC:20210922T160000
SUMMARY:\"3D genome folding\, unfolding\, and refolding in the mammalian br
ain\"
CLASS:PUBLIC
DESCRIPTION:_3D genome folding\, unfolding\, and refolding in the mammalian
brain_\n\nJennifer Phillips-Cremins\n\nDepartment of Genetics - Perelman
School of Medicine\n\nUniversity of Pennsylvania\, USA\n\n聽\n\nHosted by
Stefan Schoenfelder\n\nJoin live here - https://zoom.us/j/97304071166\n\n_
The Cremins Lab focuses on higher-order genome folding and how\nclassic ep
igenetic modifications work through long-range\, spatial\nmechanisms to go
vern synaptic plasticity in healthy and diseased\nneural circuits. Much is
already known regarding how transcription\nfactors work in the context of
the linear genome to regulate brain\ndevelopment. Yet\, severe limitation
s exist in our ability to engineer\nchromatin in neural circuits to correc
t synaptic defects in vivo. At\nthe lab鈥檚 inception\, it remained unclea
r whether and how genome\nfolding could functionally influence cell type-s
pecific gene\nexpression. We have developed and applied new molecular and\
ncomputational technologies to discover that nested subTADs and\nlong-rang
e loops undergo marked reconfiguration during neural lineage\ncommitment\,
somatic cell reprogramming\, neuronal activity stimulation\,\nand in repe
at expansion disorders. We demonstrated that loops induced\nby neural circ
uit activation\, engineered through synthetic\narchitectural proteins\, an
d miswired in fragile X syndrome were\ntightly connected to transcription\
, thus providing early insight into\nthe genome鈥檚 structure-function rel
ationship. We are currently\nfocused on understanding how\, when\, and why
3D genome folding patterns\ncontribute to synaptic plasticity and dysfunc
tion in neural circuits.\nAddressing this knowledge gap will provide an es
sential foundation for\nour long-term goal to engineer the 3D genome to re
verse pathologic\nsynaptic defects in debilitating neurological diseases._
\n\nJennifer Phillips-Cremins\, Ph.D. is an Associate Professor and Deans'
\nFaculty Fellow in Engineering and Medicine at the University of\nPennsyl
vania with primary appointments in the Departments of\nBioengineering and
Genetics. Dr. Cremins obtained her Ph.D. in\nBiomedical Engineering from t
he Georgia Institute of Technology in the\nlaboratory of Andres Garcia. Sh
e then conducted a multi-disciplinary\npostdoc in the laboratories of Job
Dekker and Victor Corces. Dr.\nCremins now runs the Chromatin Architecture
and Systems Neurobiology\nlaboratory at UPenn. Her primary research inter
ests lie in\nunderstanding the long-range chromatin architecture mechanism
s that\ngovern neural specification and synaptic plasticity in healthy neu
rons\nand how these epigenetic mechanisms go awry in neurodevelopmental an
d\nneurodegenerative diseases. She has been selected as a 2014 New York\nS
tem Cell Foundation Robertson Investigator\, a 2015 Albert P. Sloan\nFound
ation Fellow\, a 2016 and 2018 Kavli Frontiers of Science Fellow\,\n2015 N
IH Director's New Innovator Awardee\, 2020 NSF CAREER Awardee\,\nand a 202
0 CZI Neurodegenerative Disease Pairs Awardee.\n\n聽\n
X-ALT-DESC;FMTTYPE=text/html:3D genome folding\, unfolding\, and ref
olding in the mammalian brain
\n\nJennifer Phillips-Cremins
\n\nDepartment of Genetics - Perelman School of Medicine
\n\nUniv
ersity of Pennsylvania\, USA
\n\n \;
\n\nHosted by Stefan
Schoenfelder
\n\nJoin live here - https://zoom.us/j/97304071166
\n\nT
he Cremins Lab focuses on higher-order genome folding and how classic epig
enetic modifications work through long-range\, spatial mechanisms to gover
n synaptic plasticity in healthy and diseased neural circuits. Much is alr
eady known regarding how transcription factors work in the context of the
linear genome to regulate brain development. Yet\, severe limitations exis
t in our ability to engineer chromatin in neural circuits to correct synap
tic defects in vivo. At the lab鈥檚 inception\, it remained unclear whethe
r and how genome folding could functionally influence cell type-specific g
ene expression. We have developed and applied new molecular and computatio
nal technologies to discover that nested subTADs and long-range loops unde
rgo marked reconfiguration during neural lineage commitment\, somatic cell
reprogramming\, neuronal activity stimulation\, and in repeat expansion d
isorders. We demonstrated that loops induced by neural circuit activation\
, engineered through synthetic architectural proteins\, and miswired in fr
agile X syndrome were tightly connected to transcription\, thus providing
early insight into the genome鈥檚 structure-function relationship. We are
currently focused on understanding how\, when\, and why 3D genome folding
patterns contribute to synaptic plasticity and dysfunction in neural circu
its. Addressing this knowledge gap will provide an essential foundation fo
r our long-term goal to engineer the 3D genome to reverse pathologic synap
tic defects in debilitating neurological diseases.
\n\nJennifer
Phillips-Cremins\, Ph.D. is an Associate Professor and Deans' Faculty Fel
low in Engineering and Medicine at the University of Pennsylvania with pri
mary appointments in the Departments of Bioengineering and Genetics. Dr. C
remins obtained her Ph.D. in Biomedical Engineering from the Georgia Insti
tute of Technology in the laboratory of Andres Garcia. She then conducted
a multi-disciplinary postdoc in the laboratories of Job Dekker and Victor
Corces. Dr. Cremins now runs the Chromatin Architecture and Systems Neurob
iology laboratory at UPenn. Her primary research interests lie in understa
nding the long-range chromatin architecture mechanisms that govern neural
specification and synaptic plasticity in healthy neurons and how these epi
genetic mechanisms go awry in neurodevelopmental and neurodegenerative dis
eases. She has been selected as a 2014 New York Stem Cell Foundation Rober
tson Investigator\, a 2015 Albert P. Sloan Foundation Fellow\, a 2016 and
2018 Kavli Frontiers of Science Fellow\, 2015 NIH Director's New Innovator
Awardee\, 2020 NSF CAREER Awardee\, and a 2020 CZI Neurodegenerative Dise
ase Pairs Awardee.
\n\n \;
\n
DTSTAMP:20210813T160018Z
END:VEVENT
END:VCALENDAR